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Is tailored therapy based on antibiotic susceptibility effective?

Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 43-50 doi: 10.1007/s11684-019-0706-8

Abstract: An effective eradication therapy of ( ) should be used for the first time.In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is moreeffective than traditional therapy.The patients were randomly assigned to receive tailored triple therapy (TATT), tailored bismuth-containingquadruple therapy (TABQT), or traditional bismuth-containing quadruple therapy (TRBQT).

Keywords： tailored triple therapy     tailored bismuth-containing quadruple therapy     traditional bismuth-containingquadruple therapy     antibiotic susceptibility testing     eradication rates    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Crack detection of the cantilever beam using new triple hybrid algorithms based on Particle Swarm Optimization

Amin GHANNADIASL; Saeedeh GHAEMIFARD

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 9,   Pages 1127-1140 doi: 10.1007/s11709-022-0838-9

Abstract: This paper deals with the inverse analysis of the crack detection problems using triple hybrid algorithmsThe results show that among the proposed triple hybrid algorithms, the PSO-GA-FA and PSO-GWO-FA algorithms

Keywords： crack     cantilever beam     triple hybrid algorithms     Particle Swarm Optimization    

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Fabrication of titanosilicate pillared MFI zeolites with tailored catalytic activity

Baoyu Liu, Qiaowen Mu, Jiajin Huang, Wei Tan, Jing Xiao

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 772-782 doi: 10.1007/s11705-019-1859-3

Abstract: The conversion of DBT and yield of DBTS could be systematically tailored by tuning the molar ratio of

Keywords： MFI zeolite     catalysis     nanosheets     fabrication    

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Energy-efficient recovery of tetrahydrofuran and ethyl acetate by triple-column extractive distillation

Ao Yang, Yang Su, Tao Shi, Jingzheng Ren, Weifeng Shen, Teng Zhou

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 303-315 doi: 10.1007/s11705-021-2044-z

Abstract: An energy-efficient triple-column extractive distillation process is developed for recovering tetrahydrofuranSubsequently, the direct and indirect triple-column extractive distillation processes are proposed in

Keywords： extractive distillation     solvent selection     conceptual design     process optimization     heat integration    

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Improved blending strategy for membrane modification by virtue of surface segregation using surface-tailored

Shuai Liang, Peng Gao, Xiaoqi Gao, Kang Xiao, Xia Huang

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0875-5

Abstract: Two types of amphiphilic nanoparticles were prepared via silanization reaction. Amphiphilic nanoparticles tend to protrude from membrane matrix by segregation. Blending with amphiphilic nanoparticles further enhances membrane hydrophilicity. Excessive silanization cause adverse effect on blending efficiency. Membrane modification is one of the most feasible and effective solutions to membrane fouling problem which tenaciously hampered the further augmentation of membrane separation technology. Blending modification with nanoparticles (NPs), owing to the convenience of being incorporated in established membrane production lines, possesses an advantageous viability in practical applications. However, the existing blending strategy suffers from a low utilization efficiency due to NP encasement by membrane matrix. The current study proposed an improved blending modification approach with amphiphilic NPs (aNPs), which were prepared through silanization using 3-(Trimethoxysilyl)propyl methacrylate (TMSPMA) as coupling agents and ZnO or SiO as pristine NPs (pNPs), respectively. The Fourier transform infrared and X-ray photoelectron spectroscopy analyses revealed the presence of appropriate organic components in both the ZnO and SiO aNPs, which verified the success of the silanization process. As compared with the pristine and conventional pNP-blended membranes, both the ZnO aNP-blended and SiO aNP-blended membranes with proper silanization (100% and 200% w/w) achieved a significantly increased blending efficiency with more NPs scattering on the internal and external membrane surfaces under scanning electron microscope observation. This improvement contributed to the increase of membrane hydrophilicity. Nevertheless, an extra dosage of the TMSPMA led to an encasement of NPs, thereby adversely affecting the properties of the resultant membranes. On the basis of all the tests, 100% (w/w) was selected as the optimum TMSPMA dosage for blending modification for both the ZnO and SiO types.

Keywords： Membrane modification     Nanoparticle     Hydrophilic     Amphiphilic     Blending    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, althoughThese unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapy

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 165-172 doi: 10.1007/s11684-012-0196-4

Abstract: and intensity-modulated radiation therapy, proton therapy has yielded more promising outcomes in localCarbon therapy in Japan showed even more promising results than proton therapy.The non-invasive nature of particle therapy affords more patients with chances to receive and benefitParticle therapy is gradually getting attention from the oncology community.However, the cost of particle therapy facilities has limited the worldwide use of this technology.

Keywords： radiation therapy     particle therapy     proton     carbon     cancer    

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performance solid-state thermoelectric energy conversion via inorganic metal halide perovskites under tailored

Lifu YAN, Lingling ZHAO, Guiting YANG, Shichao LIU, Yang LIU, Shangchao LIN

Frontiers in Energy 2022, Volume 16, Issue 4,   Pages 581-594 doi: 10.1007/s11708-022-0831-y

Abstract: the thermoelectric device can reach as high as approximately 12% using mixed halide perovskites under tailored

Keywords： inorganic metal halide perovskites     mechanical deformation     thermoelectrics     first-principle calculations     Boltzmann transport theory    

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Passive antibody therapy in emerging infectious diseases

Frontiers of Medicine doi: 10.1007/s11684-023-1021-y

Abstract: In addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights

Keywords： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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The Cloud Control Method and Balancing Patterns of Triple Link Inverted Pendulum Systems

Li Deyi

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 41-46

Abstract:

A formal representation of cloud models for mapping between qualitative and quantitative knowledge is presented in this paper.The algorithms for producing the cloud drops are given to describe fuzziness and randomness contained in linguistic concepts. The uncertainty reasoning mechanism is proposed with such cloud models, while several qualitative rules are activated simultaneously.The cloud theory has been successfully applied to balance one-, two- and three-link inverted pendulum systems driven by single motor showing different balancing patterns and some robustness. This intelligent control technique can be used in control of robots and flying objects in space. Moreover, it may have universal significance in revealing the transformation law between qualitative and quantitative knowledge.

Keywords： intelligent control     cloud models     qualitative reasoning     inverted pendulum    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: rationale, the intriguing question is why cancers are insensitive or not responsive to mTOR-targeted cancer therapyERK, and Mnk/eIF4E survival signaling pathways that compromise the efficacy of rapalog-based cancer therapyThese new findings may also offer us the opportunity to rationally utilize mTOR inhibitors in cancer therapy

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF.Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF wereThe efficacy and safety of targeted therapy were compared with those of other systemic therapy optionsTargeted therapy does not provide considerable advantages in efficacy and safety over other medical treatmentsstudies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Hydroxyl radical-involved cancer therapy via Fenton reactions

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 345-363 doi: 10.1007/s11705-021-2077-3

Abstract: Furthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed

Keywords： hydroxyl radical     Fenton catalyst     hydrogen peroxide     cancer therapy    

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Title Author Date Type Operation

Is tailored therapy based on antibiotic susceptibility effective?

Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Crack detection of the cantilever beam using new triple hybrid algorithms based on Particle Swarm Optimization

Amin GHANNADIASL; Saeedeh GHAEMIFARD

Journal Article

Fabrication of titanosilicate pillared MFI zeolites with tailored catalytic activity

Baoyu Liu, Qiaowen Mu, Jiajin Huang, Wei Tan, Jing Xiao

Journal Article

Energy-efficient recovery of tetrahydrofuran and ethyl acetate by triple-column extractive distillation

Ao Yang, Yang Su, Tao Shi, Jingzheng Ren, Weifeng Shen, Teng Zhou

Journal Article

Improved blending strategy for membrane modification by virtue of surface segregation using surface-tailored

Shuai Liang, Peng Gao, Xiaoqi Gao, Kang Xiao, Xia Huang

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Particle therapy for cancers: a new weapon in radiation therapy

Guo-Liang Jiang

Journal Article

performance solid-state thermoelectric energy conversion via inorganic metal halide perovskites under tailored

Lifu YAN, Lingling ZHAO, Guiting YANG, Shichao LIU, Yang LIU, Shangchao LIN

Journal Article

Passive antibody therapy in emerging infectious diseases

Journal Article

The Cloud Control Method and Balancing Patterns of Triple Link Inverted Pendulum Systems

Li Deyi

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article

Hydroxyl radical-involved cancer therapy via Fenton reactions

Journal Article